The England captain knows that a win for Spurs against Ralf Rangnick’s standout side could be crucial as the race for the top four Champions League spots heats up.
After their own 5-0 loss to Everton, Kane sees their trip to the Theater of Dreams as a rare ‘opportunity’ following United’s humiliating 4-1 loss to Manchester City in the derby.
“United are still one of the best teams in the league, but obviously they had a disappointing result this weekend,” Kane said.
“There will always be a reaction and a rebound from their players and we have to make sure we are ready for that.
“But obviously we think there’s an opportunity for us there because we had a great result and we could try to use that momentum, especially away against their home crowd.”
The reverse game was United’s 3-0 win at White Hart Lane which earned Spurs manager Nuno Espirito Santo his marching orders.
Kane therefore believes Tottenham owe their former manager to repay Saturday’s time.
“They beat us earlier in the season quite comfortably,” he recalled. “We have to have all of this in our heads, we have to make sure we go there with the right mindset.
“It’s a game we’re looking forward to. Old Trafford away is one of the best games you play in the league and you have to be excited.
“You have to go out there and try to be free and put in another good performance.”
Antonio Conte is determined that Kane and Spurs treat the trip to Manchester as a cup final in their quest to qualify for the Champions League.
The Italian said: “I expect to see a great game on Saturday, not just for Harry but for the whole team.
“It’s right to celebrate but at the same time we have to be focused and from tomorrow we have to start thinking that Saturday is going to be a crucial game for us and I repeat, it’s right to celebrate the players who are making fantastic things.
“But at the same time, I want my players to celebrate but not lose focus, not lose our focus.
“We have 12 games to play and they have to be finals for us. I repeat, now I put this goal to my team that we must try to stay until the end very close to the leading team and try to do something important.
“For us to finish in the top four would be like winning the Champions League or the Premier League this season.”